SignaBlok to Present Preclinical Data on TREM-1-Targeting Drug for the Treatment of Sepsis, Pulmonary Inflammation and Fibrosis at the Respiratory Innovation Summit (RIS) and American Thoracic Society (ATS) International Conference 2025

 SignaBlok will present groundbreaking positive preclinical data detailing therapeutic activity of its leading macrophage-restricted TREM-1 inhibitor in experimental sepsis, acute respiratory distress syndrome (ARDS), and pulmonary fibrosis (PF) at the RIS and ATS Conference in San Francisco, California from May 16-21, 2025.

Shrewsbury, MA, March 24, 2025 – SignaBlok, Inc., a preclinical stage biotechnology company pioneering first-in-class, new mechanism-based peptide therapies for multiple diseases, today announced it will present positive preclinical data detailing therapeutic activity of its leading macrophage-restricted TREM-1 inhibitor in experimental sepsis, acute respiratory distress syndrome (ARDS), and pulmonary fibrosis (PF) at the RIS and ATS Conference in San Francisco, California from May 16-21, 2025.

Details on SignaBlok’s upcoming 2025 RIS and ATS poster presentations are as follows:

• In septic animals, TREM-1 blockade by SignaBlok's first-in-class macrophage-restricted TREM-1 inhibitor protects from death with the level of protection not declining at delayed treatment times

• In rats, macrophage-restricted TREM-1 blockade significantly reduces lipopolysaccharide (LPS)-induced neutrophil accumulation in the lungs when injected after, but not before, LPS challenge

• In mice with bleomycin-induced pulmonary fibrosis,TREM-1 blockade reduces the rate of progression and reverses fibrosis in the prevention and treatment models

• Data highlight potential of SignaBlok’s SCHOOL technology platform to support clinical development of TREM-1 drug with minimal risk of failure due to a new mechanism of action

Respiratory Innovation Summit:
Poster Title: Sepsis: Understanding Nature. Solving the Inflammation Puzzle. Saving Lives.
Presenter: Alexander B. Sigalov, Ph.D. (SignaBlok President and Principal Investigator)
Date / Time: Friday May 16, 2025 2 PM - Saturday May 17, 2025, 6 pm ATS International Conference:
Poster Title: Ligand-Independent TREM-1 Blockade Ameliorates Pulmonary Inflammation and Fibrosis
Presenter: Alexander B. Sigalov, Ph.D. (SignaBlok President and Principal Investigator)
Abstract Presentation Number: 9150
Session: A22 – Break on through: Airway epithelial barrier in inflammation and injury
Date / Time: Sunday May 18, 2025, 9:15 am – 11:15 am

About TREM-1
Triggering receptor expressed on myeloid cells 1 (TREM-1) serves as an inflammation amplifier. As such, TREM-1 is involved in the pathogenesis of sepsis, ARDS, PF, and other inflammatory pathologies. Clinical targeting of TREM-1 is challenging due to multiple known and still unidentified TREM-1 ligands.

About SignaBlok
SignaBlok, Inc. is a Massachusetts-based biotechnology company founded in 2009 to develop innovative, first-in-class therapeutics for targeted treatment of inflammation-associated diseases through the use of two key SignaBlok's proprietary technologies: 1) new mechanism-based approach to inhibition of cell receptors by using innovative, ligand-independent inhibitory peptides (the so-called SCHOOL peptides, the abbreviation coming from the "Signaling Chain HOmoOLigomerization" model of immune signaling); and 2) nature-inspired, multifunctional nanotechnology for targeted drug and/or imaging agent delivery to macrophages. Additional information about SignaBlok is available at www.signablok.com.

Signablok, Inc. To Present Preclinical Data on Trem-1-Targeting Drug for the Treatment of Cancer at the American Association for Cancer Research Annual Meeting 2025

 SignaBlok, Inc. will present groundbreaking preclinical data on targeting innate inflammation for the treatment of hard-to-treat cancers. In combination with standard-of-care chemotherapy, SignaBlok's new mechanism-based inhibitor of TREM-1, an inflammation amplifier, prevents cancer recurrence, improves complete response rate and survival in experimental pancreatic cancer. In combination with anti-PD-L1 treatment, it overcomes pancreatic cancer resistance to immunotherapy.

Shrewsbury, MA, USA, March 23, 2025 –  SignaBlok, Inc.. a preclinical stage biotechnology company pioneering first-in-class, new mechanism-based peptide therapies for multiple diseases, today announced it will present positive preclinical oncology data on the company's leading macrophage-restricted TREM-1 inhibitor at the 2025 AACR Annual Meeting to be held in Chicago, Illinois from April 25-30, 2025.

Details on SignaBlok’s upcoming 2025 AACR Annual Meeting poster presentation are as follows:

• In experimental pancreatic cancer, SignaBlok's first-in-class macrophage-restricted TREM-1 inhibitor:
− prevents cancer recurrence, improves complete response rate and survival, when administered after, but not concurrently with, standard-of-care chemotherapy

− reverses immunosuppression and overcomes cancer resistance to anti-PD-L1 immunotherapy

• Rodent studies indicate that SignaBlok's TREM-1 inhibitor is safe and well-tolerable

• Data highlight potential of SignaBlok’s SCHOOL technology platform to support clinical development of TREM-1 drug with minimal risk of failure due to a new mechanism of action

• Presented results have important clinical implications in the treatment of patients with not only pancreatic cancer, but also other inflammation-associated, hard-to-treat solid tumors

Poster Title: Timely resolution of TREM-1-mediated inflammation after chemotherapy improves complete response rate and survival in experimental pancreatic cancer
Presenter: Alexander B. Sigalov, Ph.D. (SignaBlok, Inc.; President and Principal Investigator)
Abstract Presentation Number: LB128
Poster Session 52: Monday April 28, 2025, 9:00 am – 12:00 pm

About pancreatic cancer (PC)
PC is the third leading cause of cancer-related death in the US. Despite recent advances, the 5-year survival rate for all stages combined is as low as 13%, necessitating the development of new approaches.

About TREM-1
Triggering receptor expressed on myeloid cells 1 (TREM-1) serves as an inflammation amplifier. As such, TREM-1 is critically involved in the pathogenesis of multiple cancer types, sepsis, rheumatoid arthritis, acute respiratory distress syndrome, scleroderma, atherosclerosis, and other inflammatory pathologies. Clinical targeting of TREM-1 is challenging due to multiple known and still unidentified TREM-1 ligands.

About SignaBlok
SignaBlok, Inc. is a Massachusetts-based biotechnology company founded in 2009 to develop innovative, first-in-class therapeutics for targeted treatment of inflammation-associated diseases through the use of two key SignaBlok's proprietary technologies: 1) new mechanism-based approach to inhibition of cell receptors by using innovative, ligand-independent inhibitory peptides (the so-called SCHOOL peptides, the abbreviation coming from the "Signaling Chain HOmoOLigomerization" model of immune signaling); and 2) nature-inspired, multifunctional nanotechnology for targeted drug and/or imaging agent delivery to macrophages. Additional information about SignaBlok is available at www.signablok.com.

Acclaimed Author A.M. Berkowitz Featured in Reader’s House Magazine

 Renowned children’s author A.M. Berkowitz has been featured in the latest issue of Reader’s House Magazine, London’s premier literary gateway.

 

London, UK, March 8, 2025 – Renowned children’s author A.M. Berkowitz has been featured in the latest issue of Reader’s House Magazine, London’s premier literary gateway.

Recognised for her exceptional storytelling and ability to inspire young readers, Berkowitz was also honoured with the Editor’s Choice Award of Literary Excellence, a prestigious accolade presented to a select group of outstanding authors.

Reader’s House Magazine, which is available in over 190 countries and thousands of stores including Amazon, Barnes & Noble, Walmart, and Waterstones, praised both Berkowitz and her literary works. Best known for the Gigglet the Happy Little Piglet series, her stories spark imagination, joy, and a love for reading among children worldwide.

In an exclusive interview, Berkowitz shared her heartfelt journey from a corporate career and operatic background to becoming a celebrated children’s author. Reflecting on her transition, she said: “I discovered my passion for writing children’s books was undeniable and would happen whether or not it was in ‘my plan.’”

The interview delves into the inspiration behind her beloved character, Gigglet, whose adventures have captivated young audiences. Berkowitz revealed that the idea for Gigglet came to her unexpectedly:

“One morning, I received a spam email that said ‘Lit Gadget’ in the subject line, but my brain read it as ‘Gigglet.’ I laughed out loud and thought, ‘That doesn’t say Gigglet, but what if it did?’ And from there, a whole world opened up.”

Berkowitz’s books are more than just stories—they encourage creativity, fun, and a deep sense of connection. Speaking about her mission, she shared: “The most important thing to remember when reading the Gigglet books is to be in the moment, have fun, follow your bliss, and ‘GET YOUR GIGGLE ON.’”

With multiple new books and exciting projects on the horizon, including the expansion of the Gigglet series, Berkowitz continues to inspire children and families worldwide.
The full interview is available in Reader’s House Magazine, Issue 49 at https://readershouse.co.uk/issue-49.



About A.M. Berkowitz
A.M. Berkowitz is a celebrated children’s author known for her imaginative and heartwarming storytelling. A former operatic mezzo-soprano and corporate professional, she found her true passion in writing, creating the beloved Gigglet the Happy Little Piglet series. Through her books, Berkowitz aims to inspire joy, creativity, and a love for reading in children worldwide. Visit her website at www.ambkidsbooks.com for more information on her work and upcoming projects.

MovPilot Introduces a New Solution for Offline Streaming — Paramount Plus Video Downloader

 MovPilot Paramount Plus Video Downloader lets user download videos in MP4/MKV formats with up to 85% off for a limited time. Enjoy fast, offline viewing with multilingual support and metadata preservation. Easily save Paramount+ movies with subtitles and no ads.

HONGKONG, CHINA – March 05, 2025 - /PressReleasePoint/ – With the ever-increasing demand for seamless offline streaming, MovPilot has introduced its latest innovation—the Paramount Plus Video Downloader. This newly launched software is designed to provide a reliable solution for those who seek high-quality offline access to their favorite Paramount Plus content.

MovPilot – Meeting the Growing Demand for Offline Streaming
The digital entertainment landscape continues to evolve, with audiences expecting greater flexibility in how they watch their favorite shows and movies. Streaming platforms offer extensive content libraries, but internet connectivity issues and platform restrictions often limit viewing experiences. Recognizing this need, MovPilot has developed a Paramount Plus Video Downloader that allows users to download and enjoy Paramount Plus content anytime, anywhere, without limitations.
This software is built with a focus on efficiency, ensuring that high-resolution videos can be stored securely for offline playback. By bridging the gap between streaming convenience and offline accessibility, MovPilot provides a solution tailored to modern entertainment habits.

Key Features of MovPilot Paramount Plus Video Downloader
The MovPilot Paramount Plus Video Downloader is equipped with a range of features designed to enhance the downloading and viewing experience:

• High-Quality Downloads – Supports up to 1080p full HD resolution, ensuring that videos retain excellent visual clarity.

• DRM-Free Format Choices – Store videos in MP4 or MKV format, ensuring compatibility with all devices and media players.

• Subtitles and Audio Tracks Preservation – Maintains multiple language options for subtitles and audio tracks, catering to diverse viewer preferences.

• Ad-Free Playback – Downloads videos without advertisements, allowing uninterrupted entertainment.

• Fast and Stable Performance – Utilizes advanced technology to ensure quick 5X faster and reliable downloads with minimal buffering.

• Compatibility with Multiple Devices – Enables seamless transfer and playback across Windows, Mac, smartphones, and tablets.

By incorporating these features, MovPilot ensures that Paramount Plus subscribers have an optimal offline viewing experience, free from the constraints of an active internet connection.

Pricing Plans and Special Promotions
MovPilot Paramount Plus Video Downloader is available at competitive pricing, ensuring accessibility for various streaming needs. To celebrate the launch, limited-time discounts are being offered across different subscription plans and bundled options.

1. Standard Plans for MovPilot Paramount Plus and Other Platforms

For those who require a downloader for a single streaming service like Paramount+, Netflix, Amazon Prime, Disney+, HBO Max, and Hulu, MovPilot offers flexible plans:

• 1-Month Plan – Originally priced at $39.95, now available at $35.96 (10% OFF).

• 1-Year Plan – A significant discount of 85% OFF, bringing the price down to $59.95 (just $4.99/month).

 

2. MovPilot All-in-One Video Downloader

For users seeking a comprehensive solution, MovPilot’s all-in-one downloader supports multiple platforms, including Netflix, Amazon Prime, Disney+, HBO Max, Hulu, and Paramount Plus:

• 1-Month Plan – Reduced from $49.95 to $44.95 (10% OFF).

• 1-Year Plan – Enjoy 80% OFF, making it just $99.95 ($8.33/month).

• Perpetual Plan – A one-time payment of $134.95 (10% OFF, originally $149.95) ensures lifetime access.

 

3. Special Bundle Offers

For users managing multiple streaming subscriptions, MovPilot offers discounted bundle deals, combining two services at once:

• Netflix + Amazon Prime Downloader – 35% OFF, now $116.94 (was $179.90).

• Disney Plus + Hulu Downloader – 35% OFF, now $116.94 (was $179.90).

• Netflix + Paramount Plus Downloader – 30% OFF, now $125.93 (was $179.90).

These promotional prices are available for a limited time, providing an excellent opportunity for users to secure uninterrupted offline access to their favorite content at the best possible value.

How to Get Started with MovPilot Paramount Plus Video Downloader
Getting started with MovPilot is simple and requires only a few steps:

1. Download and Install – Install the MovPilot Paramount Plus Video Downloader from the official website.

2. Log in to Paramount Plus – Launch the software and sign in to a valid Paramount Plus account.

3. Search for Content – Use the built-in search function to find the desired movies or TV shows.

4. Select Download Preferences – Choose the preferred resolution, subtitle settings, and audio tracks.

5. Start Downloading – Click the download button and enjoy seamless offline playback once the process is complete.

The intuitive design of the software ensures that even first-time users can navigate the process with ease.

A Valuable Tool for Offline Streaming Enthusiasts

For those who frequently travel, experience unstable internet connections, or simply wish to build a personal offline library of Paramount Plus content, the MovPilot Paramount Plus Video Downloader serves as a highly valuable tool. By offering high-definition downloads, customizable playback options, and an ad-free experience, this software caters to modern streaming preferences with efficiency and reliability.
As the demand for offline viewing solutions continues to rise, MovPilot remains committed to delivering user-friendly, high-performance software that enhances digital entertainment experiences. Take advantage of MovPilot special promotions today and enhance the streaming experience!

About MovPilot
MovPilot is a leading software developer specializing in high-quality video download solutions for popular streaming platforms. With a mission to provide seamless offline viewing experiences, MovPilot continuously innovates to meet the evolving demands of digital entertainment. The company's products are known for their efficiency, reliability, and ease of use, making MovPilot a trusted choice for streaming enthusiasts worldwide.

Skyseal is Now Proudly Owned by its Employees

 Coventry-based Optagon Group, which owns Skyseal, a specialist provider of roof lights, has moved to Employee Ownership Trust for its 50-strong workforce, which now owns the majority of the company.

Coventry, Warwickshire, United Kingdom., February 21, 2025 – Coventry-based Optagon Group, which owns Skyseal, a specialist provider of roof lights, has moved to Employee Ownership Trust for its 50-strong workforce, which now owns the majority of the company.

First established in 2010 and based in Swallowgate Business Park, Coventry, Optagon owns and operates a family of brands. These include Rubber4roofs, Skyseal, SkyGuard and Kitbuildr.

Optagon, which has established a nationwide presence, can ship to anywhere in the UK and offers drop-ship services for other online retailers through its national distribution network.

The move to employee ownership was motivated by an offer from a larger organisation to buy the business. However, the founders, Tom and Tina Cullingford, turned it down to let the staff be in charge of the company's destiny.

Explaining the decision, Tom and Tina Cullingford stated: “Building a company requires hard work and determination, but creating a great business takes a great team. In 2023, a large organisation approached us with an offer to acquire the business, prompting significant reflection. While the offer was attractive, we ultimately decided that the company’s future should be shaped by those who contribute to its success every day.”

Tom Cullingford will remain as managing director, continuing to lead the company alongside a senior leadership team. He will be joined on the board by two newly appointed legal directors, general manager Antony Murray, and finance director Zoe George.

Reflecting on the transition, Antony Murray commented: “When Tom and Tina first mentioned transferring ownership to the entire team, it was both a surprise and an exciting opportunity. This move is a testament to the strength of the team and the success we have built together. The journey ahead presents a learning curve, but being part of such an innovative and forward-thinking organisation is an incredible opportunity. Every member of the team now has a meaningful stake in Optagon’s ongoing success.”

Employee-owned corporate finance adviser BCMS supported the shareholders and senior team throughout the transaction.

Tom and Tina Cullingford added: “A special thank you to the BCMS team for their guidance and support in ensuring a seamless transition to employee ownership. Their people-first approach, hands-on assistance, and expertise in areas such as valuation and communication were invaluable. Most importantly, having BCMS involved allowed the senior team to remain focused on running the business without disruption.”;

About Skyseal

Skyseal is a trading name of Optagon Ltd and exists to provide builders, roofers and competent DIY’ers with a wide variety of modern roof light options. Formerly known as Roof Depot, our company has been a trusted name in the skylight and roof window industry for years. As we transition to our new brand, Skyseal, we remain committed to delivering the exceptional products and services customers have come to expect. We are passionate about modern roofing solutions and the most up-to-date technologies in the skylight world. With our 3D configurator, we ensure our customers can find the perfect skylight for their properties and build it to their exact needs with ease, whilst ensuring longevity in their choices. You wouldn’t build a house and expect it to last only 10 years, so why do we put up with this when it comes to your roof!

Lance Reegan-Diehl Makes Top Ten Guitarist List in Vancouver

 Steve Newton Interviews and Comments While Comparing Sound to Satriani

Vancouver, BC — February 4, 2025— Lance Reegan-Diehl was recently included in the Top Ten List of Vancouver guitarists on writer Steve Newton’s site - Ear Of Newt, music writer/critic for The Georgia Strait. The timing couldn’t be better and coincided with the release of a video for "Sleepy Wheel," a track from his Maniacal Cavern album. This album, a testament to Reegan-Diehl's musical versatility and creativity, features a unique blend of rock, jazz, and blues and has been well-received by music enthusiasts. “Sleepy Wheel” – Features Producer/Bassist Kevin Stuart Swain (THOR, Al Harlow) on the track.

Maniacal Cavern was the 15th studio album that Lance had produced, and his 29th record that he has recorded on, played on, been a session guitarist, and/or otherwise been a part of.

Lance Reegan-Diehl is a Guitarist, Composer, Producer, and clinician who has lived in Korea for many years. He endorses Chapman Guitars, Sound Drive Amplification, Olympia Strings, and Graphtech Guitar Parts.

He is also known for his steadfast support of the U.S. Military and events that help that community, a contribution that his audience profoundly appreciates.

Reegan-Diehl's fluid guitar style and technical prowess allow him to play any music exceptionally well. His recordings of instrumental guitar albums have created a legacy that many of his contemporaries have not enjoyed.

His energy and unwavering love for music continue to this day, with many projects simultaneously inspiring his audience with his passion.

About Lance Reegan-Diehl

Lance Reegan-Diehl (L.R.D.) is a guitarist hailing from Vancouver B.C. and an enduring talent in the music industry with his guitar work appearing on several albums, and his own solo releases and L.R.D. Band releases. His music work in and out of the studio is a testament to his talent and affinity for creating magic and transferring it to the listener via the digital and analog methods, live performances, and clinics. Lance is the epitome of the indie artist with the necessary fortitude and drive to succeed in a competitive market. He is the consummate musician, producer, clinician, businessman, and an example to anyone that wants to succeed in the music industry. The guitarists work has also appeared on several albums and singles over the years. 

Marcu Ioachim Shop Launches Exclusive Collection of Custom Art and Products on Redbubble

Explore a Range of Unique and Artistic Designs for Apparel, Home Decor, Accessories, and More

 

Cugir,Alba,Romania., February 3, 2025 - Marcu Ioachim Shop, a creative online shop, is proud to announce the launch of its exclusive collection of custom artwork and designs  available on Redbubble. Featuring a wide variety of unique illustrations, the shop offers one-of-a-kind products including apparel, home decor, stationery, accessories, and more – all designed to help customers express their personal style and creativity.

From vibrant, eye-catching illustrations to minimalist, thought-provoking designs, Marcu Ioachim Shop brings fresh and diverse art to life on high-quality, customizable items. Each product is crafted with care, ensuring that every customer receives a unique, artistic piece that resonates with their individuality.

Marcu Ioachim Shop is built around the idea of merging artistic expression with everyday life. Whether customers are seeking a statement piece to wear, decor to transform their living space, or a gift that stands out, Marcu Ioachim Shop offers a wide selection of products that are both beautiful and functional. Available items include t-shirts, hoodies, phone cases, stickers, tote bags, pillows, posters, and much more.

Marcu Ioachim Shop is not just about creating beautiful art—it's about fostering a sense of personal connection to the designs. Each product is made to order, ensuring that customers receive a piece that is not only unique but also crafted with care and attention to detail. The shop’s commitment to quality is reflected in the range of premium materials and printing options available, giving customers the freedom to choose from a wide variety of colors, sizes, and styles to best suit their preferences.

As an independent artist, Marcu Ioachim Shop embraces the power of creativity and individuality. "I want to encourage people to explore their personal style through art and design," the creator explained. "Redbubble’s platform provides the perfect way to make that possible. It allows me to share my work with a global audience, and for customers to access high-quality products that make them feel like they’re wearing or living in a piece of art."

1. Product Highlights:

• Apparel: Choose from a range of clothing including t-shirts, hoodies, tank tops, and more with exclusive designs.
• Home Decor: Personalized wall art, posters, cushions, blankets, and more to brighten up any living space.
• Accessories: Stylish phone cases, tote bags, and stickers that add flair to everyday essentials.
• Stationery: Notebooks, journals, and greeting cards with artistic touches to make every written word special.

"We're excited to bring our designs to the Redbubble platform," said the creator behind Marcu Ioachim Shop. "Whether you're looking for something bold and expressive or simple and elegant, there's something here for everyone. I want to provide people with art that connects with them on a personal level, and Redbubble’s print-on-demand platform allows for the perfect blend of creativity and customization."

The shop is now live and ready to serve customers worldwide, offering both domestic and international shipping options. All items are made to order, ensuring that each piece is carefully printed and packaged with the utmost attention to detail.

Marcu Ioachim Shop invites customers to explore its full range of products and find the perfect piece to elevate their wardrobe, home, or gifting experience. With new designs being added regularly, there’s always something fresh and exciting to discover.



About Marcu Ioachim Shop:
Marcu Ioachim Shop is an independent art shop on Redbubble, created by an artist with a passion for crafting unique and imaginative designs that transform everyday items into personalized, wearable art. Offering a wide range of customizable products including clothing, home decor, accessories, and more, Marcu Ioachim Shop combines creativity with quality, providing customers with a fresh way to express their individual style. With a commitment to originality and a growing collection of designs, Marcu Ioachim Shop is dedicated to making art accessible and meaningful to people everywhere.